The so-called UV-Model has shown to be a useful method for the determination of the anti-inflammatory effect of a substance. In the UV-Model the reddening index and capillary skin circulation in 1 mm depth in the respective test areas are determined prior to and at various times after UV irradiation.
This method is also used for proving anti-inflammatory efficacy of test substances. The size of erythema and wheals is determined after the injection of a histamine solution compared to an untreated control field and 1 % hydrocortisone cream. Additionally, subjectively perceived itchiness can be documented in the histamine-wheals test.